Expectancies, placebo and nocebo in pain and other medical and psychological disorders

Period: Oct 21, 2020 - Oct 21, 2020
Status: laufend

A placebo is a component of treatment or a treatment with unspecific therapeutic effect, while the so called placebo response is the positive effect that is caused by this treatment. The placebo response is probably caused by factors such as patient expectations, the patient-doctor relationship and conditioning processes. Nocebo response refers to negative effects that are caused by nonspecific treatment components or treatments. In our research we investigate different aspects on placebo and nocebo responses in pain and other conditions such as depression.

Project partner

Prof. Dr. Winfried Rief, University of Marburg


University of Marburg Research Funds


Ostbahnstr. 10 (3. OG, 3.1.11), 76829 Landau
+49 6341 280-35645
glombiewski at uni-landau.de
Ostbahnstraße 10 (3. OG, 3.1.06); 76829 Landau
+49 6341 280-35652
kube at uni-landau.de



Auer, C. J., Glombiewski, J. A., Doering, B. K., Winkler, A., Laferton, J. A. C., Broadbent, E., & Rief, W. (2016). Patients’ Expectations Predict Surgery Outcomes: A Meta-Analysis. International Journal of Behavioral Medicine, 23(1), 49–62.

Kube, T., Glombiewski, J. A., & Rief, W. (2018). Using different expectation mechanisms to optimize treatment of patients with medical conditions - A systematic review. Psychosomatic Medicine, 80(6), 535-543. doi: 10.1097/PSY.0000000000000596

Rief, W., & Glombiewski, J. A. (2012). The hidden effects of blinded, placebo-controlled randomized trials: An experimental investigation. Pain, 153(12), 2473–2477.

Rief, W., Barsky, A. J., Glombiewski, J. A., Nestoriuc, Y., Glaesmer, H., & Braehler, E. (2011). Assessing general side effects in clinical trials: Reference data from the general population. Pharmacoepidemiology and Drug Safety, 20(4), 405–415.