Number of cases campus Landau: 1 (warning level Gelb until 01.02.2021) Action plan

Mechanisms of open-label placebos

Period: Jan 16, 2021 - Jan 16, 2021
Status: laufend

Until recently, it was thought that patients had to believe that placebos contained active medication in order to elicit a placebo response. However, recent studies have questioned this assumption by showing that placebos are still effective when being administered to patients with full transparency and disclosure (so-called ‘open-label placebos’, OLPs). In this project, we are investigating the underlying mechanisms of OLPs. In particular, we are examining expectancies, hopes, learning experiences, and patient-physician-communication as possible mechanisms. For this purpose, we are focusing on experimentally induced pain and sadness. Prospectively, we aim to examine mechanisms of OLPs in clinical samples, such as individuals with chronic pain and major depression.

Project partner

Prof. Dr. Winfried Rief (University of Marburg)


University of Marburg Research Funds


Ostbahnstraße 10 (3. OG, 3.1.06); 76829 Landau
+49 6341 280-35652
kube at
Ostbahnstr. 10 (3. OG, 3.1.11), 76829 Landau
+49 6341 280-35645
glombiewski at



Preregistration: Clinical Trials - Study 1 / Study 2